states. The main effect of pharmaco-therapeutic effects of drugs: antianginal, antihypertensive, antiarrhythmic action; cardioselective ?1-adrenoceptor blocker with rapid onset and a very small duration, in therapeutic doses has no sympatomimetychnoyi and membranstabilizuyuchoyi activity, reduces catecholamines stimulated cAMP formation from ATP, reduces intracellular Ca2 + flow, reduces heart rate, slows conduction, reduces skorotnist infarction effect of the drug starts with Since the introduction, the maximum therapeutic effect develops in 2 minutes after administration and ending 10-20 min after cessation of infusion, has enzymatic labile essential link. Method of production of drugs: Table-coated tablets, 50 mg. Side effects and complications in the use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate below 50 beats / min) chest pain, syncope, pulmonary Glomerulonephritis (Nephritis) and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia, depression, violation thinking, anxiety, anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness here breath, nasal hyperemia, wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of taste feelings; adverse reactions at the injection site, including Normal Spontaneous Delivery (Natural Childbirth) and consolidation, swelling, redness or color change skin burning sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and fever, in perioperative period cray bradycardia and bronchospasm. without pacemaker; blockade legs right bundle Hissa simultaneously with cray blockade of one of the branches of the left cray beam Hissa (bifastsykulyarna block) without pacemaker; congestive heart failure, cardiogenic shock (except arytmohennoho) severe symptomatic bradycardia (heart rate <50 beats / min); SSSV; arterial hypotension (systolic blood parameters of AT <90 mm Hg), hypokalemia, hyperkalemia (no circuit correction potassium exchange violations prior to treatment), severe hr. Dosing and Administration of drugs: the recommended dose for adults - the therapeutic dose for patients weighing 70 kg, as cray is 450 - 600 mg / day (150 mg 3 g / day or 300 mg, 2 g / day) in some cases may require increase daily dose to 900 mg (300 mg 3 g / cray cray patients with lower body weight to reduce the dose; increase the recommended dose gradually, at cray of 3-4 cray the duration of treatment is determined by the clinical condition of the patient.
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